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Monday, December 5, 2011
Sunday, December 4, 2011
Google looks to compete with Amazon Prime, offer speedy delivery service in 2012
You ordered a nifty thing. Now the nifty thing has to make your day by arriving. Then you'll have your nifty thing and a warm and nifty feeling inside. Evidently, Google's following this very line of thinking, as it appears to be in talks with various retailers and shippers to create a service that lets customers receive their wares within 24 to 48 hours. According to sources cited by the Wall Street Journal, the company's effort is motivated by the success of Amazon's Prime service, which allows customers to receive many purchased items within a day or two for an annual fee of $79. Google, in turn, has apparently pitched the project to retailers such as Macy's, Gap and OfficeMax. Under the proposed system, when shoppers place an order on an affiliate's website, Google's system could kick in to offer them an option for same-day or possibly next-day delivery, said a person familiar with the matter. Sources indicated that Google plans to start a pilot test of the service in the San Francisco Bay Area sometime in 2012, which -- by then -- we'll have far more serious issues to deal with than tracking numbers.Google looks to compete with Amazon Prime, offer speedy delivery service in 2012 originally appeared on Engadget on Thu, 01 Dec 2011 22:44:00 EDT. Please see our terms for use of feeds.
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Motherf*cking Wasps Recognize Each Other By Their Faces [Science]
Saturday, December 3, 2011
Review: Apps to make holiday shopping easier (AP)
SAN FRANCISCO ? Even if you love to shop, it can be a pain this time of year. Stores are crowded, gift options seem endless and it's hard to determine if you're getting the best prices.
If you have a smartphone, though, there's a simple solution: Apps. There are tons of mobile apps to help you save time and cash this holiday season. Most of them are cheap or free.
I tried several apps meant to ease holiday shopping frustrations and found a bunch that make the task easier ? and a few that make it more fun.
Price Check by Amazon and RedLaser (free, available for iPhone and Android) ? With these two apps on my phone, I felt like a low-price-finding machine. Both let you search for items by typing in the name or by scanning a barcode. With Price Check, you can also search for items with your voice or by taking a photo of things like books and DVDs.
RedLaser, owned by eBay Inc., is great for finding items online and in nearby bricks-and-mortar stores. I found myself checking prices on everything from watches to collapsible water bottles, sometimes just for the heck of it. I used it at a local Sur La Table cookware store to compare prices on a set of water glasses before buying them, and was pleased to see the $19.99 price was lower than at some online retailers and a nearby Bloomingdales department store.
RedLaser also includes a handy feature for making simple shopping lists, and a history feature that records all the items you've looked up, so you can go back and find things later on.
Price Check's layout is slightly more attractive than RedLaser's, though it's limited to the Web since it gives online-only results from Amazon.com and companies that sell through Amazon.com Inc.
I really like the way Price Check displays search results, with the product at the top of the screen and three tabs that let you quickly scroll through prices, a description and user reviews. And if I found an item's price was lower online than in the store, it would be simple to buy it through the app.
The best part about Price Check is the abundance of product reviews (the same ones you see when you go on Amazon.com or use the Amazon Mobile app). They're indispensable for looking up potential gifts and helping me think twice before making purchases.
Gift Plan ($2.99, available for iPhone) ? If you have a hard time organizing your gift list, or tend to misplace it after writing it out, you'll like Gift Plan.
The app lets you make elaborate gift lists for family and friends. You can set up lists of potential presents, jot down people's likes and dislikes and ? even more helpful for those of us who never remember such things ? their clothing sizes. The app's "Occasions" tab shows you upcoming holidays or birthdays, and a "Shopping" tab helps you track gifts you plan to buy.
Gift Plan denotes each gift-giving occasion with a different color, which makes it easy to spot them on the app's built-in calendar, and you can choose when and how often you want to be notified about upcoming events.
Another cool feature: You can set up a passcode to keep sneaky loved ones from snooping at your list.
Shopkick (free, available for iPhone, Android) ? Shopkick essentially turns shopping into a game, where you get real-world rewards for going to local stores. If you hate shopping, this can make a painful activity more fun. If you adore shopping, the app may be harmful to your wallet.
The app shows a list of nearby stores, each of which you get a certain number of "kicks," or points, for visiting. Click on a listed store and you can see available deals and opportunities to pick up more kicks (if I stopped at a local Best Buy, for example, I could get 75 kicks for scanning photos of three different GPS devices). You can also link your Visa debit or credit card to your shopkick account so you'll automatically get points for certain purchases. Collect enough "kicks" and you can get rewards such as gift certificates to Target or Best Buy.
I quickly got sucked into visiting as many nearby stores as possible, including some I rarely enter, simply so I could rack up more points. Somehow, I also ended up buying several items for myself ? fleece pajama pants at Old Navy, a white sake bottle and matching cups at Crate & Barrel ? even though I was supposed to be buying gifts for others.
Lemon (free, available for iPhone, Android, BlackBerry, Windows Phone) ? As you spend, receipts pile up. For me, this means a wad of disorganized paper slips in my wallet and digital receipts lost in the bowels of my email inbox. Lemon offers a sweet solution.
Once you download the app and sign up with its corresponding website, Lemon.com, you can scan your receipts with your phone's camera and the service will automatically identify the name and location of the store along with the amount you spent and the purchase date (if you want to see the whole receipt image, that's saved, too). Lemon is good for online shopping, too: If you buy anything on the Web, you can have online retailers send the receipt to your lemon.com address so they'll be easier to keep track of. And if you want to back up some old e-receipts with the service, just forward them there yourself.
You can use preset labels like "personal" and "credit card" to add details to your receipts, or add your own. I made a "gift" label to identify holiday items and was happy to see I could also view them by category.
The holidays can be stressful, but with a couple of these apps on your smartphone you'll likely find gift-giving less so. Your wallet might even thank you for it, too.
___
Rachel Metz can be found on Twitter at http://twitter.com/rachelmetz
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Friday, December 2, 2011
Gaming
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Missing Lincs
Nearly everybody knows that Frank Lloyd Wright designed Fallingwater, the house in Pennsylvania that sits above and appears to cascade into a waterfall. I.M. Pei?s glass pyramid at the Louvre in Paris is similarly famous. And Frank Gehry is widely known for the curvi?linear shining steel Walt Disney Concert Hall in Los Angeles.
But most people couldn?t name the contractors and subcontractors responsible for translating those great architects? blueprints into solid structures.
Geneticists have the same problem. Details for erecting an organism?s structure are encoded within DNA, written in chemical subunits designated by the letters A, T, C and G. But it has been hard to say exactly who takes those details and oversees the construction of the organism from proteins and other molecular materials.
Only now have scientists begun identifying the previously invisible contractors who make sure that materials get where they are supposed to be and in the right order to build a human being or any other creature. Some of these little-known workers belong to a class of molecules called long intergenic noncoding RNAs.
Scientists used to think that these ?linc?RNAs? were worthless. As their name suggests, these molecules ? at least 200 chemical letters long ? do not encode information that the body?s manufacturing machinery can use to cobble together proteins. And the lincRNAs originate in what scientists used to view as barren wastelands between protein-coding genes. But new research is showing that these formerly underappreciated workers have important roles in projects both large and microscopic.
?They regulate every process under the sun,? says John Rinn, an RNA researcher at Harvard Medical School.
In the last few years, scientists have learned that lincRNAs, as well as other RNAs that are long and noncoding but not intergenic, perform a variety of jobs. Some serve as guides showing proteins where to go, while others tether proteins to different types of RNA, or to DNA. Some work as decoys, distracting regulatory molecules from their usual assignments. Some may even have multiple roles, all the while chattering away to other RNA within cells. (It is not idle gossip; RNA communication within cells may ward off diseases such as cancer.) And as the ultimate multitaskers, lincRNAs keep proper cellular development ticking along and help define what makes mice mice and people people.
New ?genes?
LincRNAs are just one type of multitalented RNA that has until recently been undervalued. While DNA has been revered as a precious archive housing genetic secrets, RNA ? a chemical cousin copied from DNA ? has long been viewed as little more than an errand boy. The name of one important type of RNA that goes on to make proteins, messenger RNA, reflects that bias. Two other types of RNA, transfer RNA and ribosomal RNA, help read messenger RNA during protein creation, leaving many scientists to assume RNA?s only job was as a low-level employee on the protein production line.
That notion began to change when researchers with the Human Genome Project finished compiling the human genetic archive a decade ago. That archive contains about 3 billion genetic letters, far more than the genomes of less complex organisms such as roundworms and fruit flies. But the project revealed that people?s roughly 22,000 protein-specifying genes don?t greatly outnumber those found in simpler organisms.
The finding was one of the biggest surprises in biology. An average C. elegans roundworm contains just 959 cells; the human brain has an estimated 100 billion neurons ? more than the total number of cells in 100 million roundworms. How could it be that the same set of building materials used to construct simple lowly worms could also produce vastly more complex humans? It turns out that, in the same way a bucket of LEGOs or an Erector Set can yield an array of toy structures depending on how the pieces are put together, the answer lies in assembly.
One of the first clues to the importance of assembly came from the FANTOM project (for ?functional annotation of the mammalian genome?), an ongoing international effort to identify every piece of RNA made in a mammalian cell. In 2005, the research revealed that even though genes that code for proteins make up only 1.5 percent of the mouse genome, more than 63 percent of the genome?s DNA is copied into RNA. In humans the number is even higher, with up to 93 percent of the genome made into RNA, even though protein-coding genes make up less than 2 percent of the genome.
At first, many scientists didn?t know what to make of the excess RNA. Some thought it was overexuberance on the part of the DNA-copying machinery. But gradually researchers began to realize that many of those extra RNAs had important jobs to do.
If RNAs can do important work without making proteins, the definition of a gene needs to be expanded, says Leonard Lipovich, a geneticist at Wayne State University in Detroit. ?You realize there are not 20,000 genes; there are 40,000.?
Last year, Lipovich and colleagues reported in the journal RNA that they had found evidence of 6,736 long noncoding RNAs encoded in the human genome. Some estimates suggest that the human genome may encode more than 10,000.
Further work, reported by John Mattick of the University of Queensland in the June issue of FEBS Letters, suggests that the number of noncoding RNAs of all types is greater in humans than in other primates and greater in those primates than in mice. The same logic follows on down to puffer fish, fruit flies and beyond.
With so many long noncoding RNAs floating around in cells, the next question to answer is what do they do. ?For the vast majority, we have absolutely no idea,? says Ahmad Khalil of Case Western Reserve University in Cleveland.
Some, though, appear to act like general contractors ? not hammering in the nails and pouring the foundations of cells themselves, but dictating how the job should be done.
Long lineup
One of the most famous long noncoding RNAs, known as XIST, is also one of the most hands-on. XIST is in charge of shutting down one of the X chromosomes in every single cell of women and girls. Women and other female mammals have two copies of the X chromosome, while males have one X and one Y chromosome. Having a double dose of X chromosome genes could be harmful, even lethal, so women turn one off. XIST ? a ?lncRNA? because it is 19,000 letters long, noncoding but not intergenic ? directs the decommissioning.
XIST doesn?t have a long commute to work; it coats whichever X chromosome makes it, preventing other genes on the chromosome from being activated. XIST isn?t made in males; a partner long noncoding RNA called TSIX (XIST spelled backward) helps keep the other X chromo?some in women in working order.
One of the most well-studied linc?RNAs, named HOTAIR, wasn?t lucky enough to get a job close to home. It is copied from DNA on chromosome 12 but has to travel to chromosome 2 to shut down several genes in a group known as the HOXD cluster, genes important for proper development of an organism, Rinn and colleagues reported in Cell in 2007. A study reported last year in Nature, from Stanford University genomicist Howard Chang and his colleagues, showed that HOTAIR works at 854 different job sites.
Not only does HOTAIR help direct development, but it is also important throughout life to help cells pinpoint their location in the body.
Breast cancer cells are full of HOTAIR, especially those that migrate throughout the body, Chang?s team reported in the same paper in Nature. Cells in about a third of breast tumors studied made more than 125 times as much HOTAIR as normal breast cells do. And when copies of HOTAIR pile up in cancer cells, the cells start to drift away from the tumor. Having too much of the lincRNA appears to reprogram a cell?s internal compass, says Chang, who is also a Howard Hughes Medical Institute scientist. ?It?s kind of like a car driven by a faulty GPS device.?
Whether promoting health or mis?directing cells, lincRNAs don?t necessarily act alone. HOTAIR and some other lincRNAs direct crews of proteins known as histone modifiers. Histones are spoollike proteins that wrap up DNA so it can fit inside the cell nucleus. Where the histones sit along the DNA and how tightly the DNA is wrapped around them affects whether genes are turned on or off. HOTAIR works a bit like a surveyor putting chemical tags on histones associated with genes that need to be put under tight wraps. The lincRNA does this by bringing two different groups of proteins to selected genes. One of the protein groups plasters a closed sign on a histone protein, signaling that the gene is not open for business, while the other group rips down billboards advertising for the gene, Chang?s group reported last year in Science.
A lincRNA known as HOTTIP also works with a crew of histone modifiers, but instead of shuttering genes, HOTTIP?s crews hang grand-opening signs to attract gene-activating machinery. Working in concert with proteins, these and other lincRNAs can precisely control which genes are turned on and when ? a precision necessary to coordinate the untold steps that go into cooking up a human.
Contractor communication
In the recipe for humans, lincRNAs are in the thick of things from the very beginning. At least 26 different lincRNAs need to be on to keep an embryonic stem cell a stem cell, Rinn and his colleagues reported in the Aug. 28 Nature. As stem cells transform into various types of cells, they turn off some specific lincRNAs and turn on others, creating a mix of activity that can define the cell.
?They describe a cell?s identity better than protein-coding genes do,? says Rinn, who is also affiliated with Beth Israel Deaconess Medical Center and the Broad Institute of MIT and Harvard. He and his colleagues have developed computer software that attempts to pinpoint a cell?s type by looking at which lincRNAs it makes.
In a molecular name-that-cell contest, lincRNAs beat out proteins. Each type of cell has such a special mix of lincRNAs that the computer program can correctly identify a cell from only two lincRNAs, while four or five proteins are required for a positive ID.
Just how lincRNAs choose which genes to turn on and off isn?t yet known. But Pier Paolo Pandolfi, a geneticist at Beth Israel Deaconess and Harvard Medical School, suspects that the lincRNAs are whispering to each other and to other RNAs, keeping tabs on all a cell?s goings-on. Pandolfi laid out his hypothesis for how this chatter might help control protein production and other processes in the Aug. 5 Cell.
Protein-coding messenger RNAs are often prevented from making their instructions into proteins by tiny snippets of RNA called microRNAs. The microRNAs glom on to certain messenger RNAs like paparazzi crowding a celebrity.
If lincRNAs and messenger RNAs share a string of chemical letters that interest the microRNAs, the lincRNAs can serve as a decoy, distracting microRNAs so messenger RNAs can get their jobs done. As long as two molecules both have the signatures that the microRNAs seek, the little RNAs will clamor around both messages with equal fervor.
Last year, Pandolfi?s group found that the RNA copied from a pseudogene (a defunct copy of a gene that no longer makes proteins) can attract microRNAs away from the messenger RNA copied from a real gene called PTEN, which is important in protecting against cancer (SN: 7/17/10, p. 14). That finding led to the suggestion that, by acting as decoys, RNAs could regulate protein production or other processes within a cell. Pandolfi calls this idea the ceRNA hypothesis (for ?competing endogenous RNA?).
A growing body of evidence suggests that Pandolfi?s hypothesis is more than just a clever idea. Researchers at Columbia University performed a computerized search of the human genome and found 7,000 genes whose messenger RNA copies could act as microRNA decoys in 248,000 interactions, a result reported in the Oct. 14 Cell.
The Columbia team and Pandolfi?s team independently found that tweaking levels of a few messenger RNAs that distract microRNAs from PTEN messenger RNA can lead to prostate cancer or a type of brain tumor called glioblastoma. Just messing with levels of a messenger RNA from another gene known as ZEB2 throws off PTEN protein levels and can lead to melanoma in mice, Pandolfi?s group reported in another paper in the Oct. 14 Cell.
Some lincRNAs also appear to contain microRNA magnets. Researchers from Italy report in the same issue of Cell that they have found an RNA called linc-MD1 that is important in muscle development. The lincRNA sponges two microRNAs away from the messenger RNA of two genes, allowing more muscle-building proteins to be made from those genes. Cells taken from people with Duchenne muscular dystrophy have lower levels of linc-MD1 than normal muscle cells do. Without linc-MD1 to draw them away, the microRNAs pile on to the messenger RNAs and prevent the muscle proteins from being made.
With so many interconnected parts in the system, researchers need to think carefully about the consequences of tweaking levels of any RNA within a cell, Pandolfi says.
If any decoy isn?t made, potentially hundreds of conversation partners could be affected, with amounts of proteins they each produce being altered by 10 to 30 percent.
?People say, ?that?s ridiculous. That?s nothing,? ? Pandolfi says. But if 200 or more conversation partners are each perturbed by 10 percent, ?that?s devastating.?
Losing one noncoding RNA may be disastrous for a cell, but for want of noncoding RNAs whole species may never have evolved, argues Queensland?s Mattick. He and others say the real function of lincRNAs is to give evolution a sort of molecular clay from which to mold new designs.
New proteins rarely appear, leaving evolution a limited set of building materials to work with, Mattick says. But new lincRNAs pop up all the time; some of them appear in only one species. Given the molecules? jobs as directors and overseers, evolution may use them to make design variations on the fly.
Humans have several lincRNAs that are found in no other species. Many of those RNAs are made in the brain, leading scientists to speculate that the molecules may be at least partially responsible for that important organ?s evolution.
If Mattick is right, making a human from the same building materials used to create roundworms and fruit flies doesn?t pose such a puzzle. It does, however, mean finding the right contractors.
?LincRNA? lingo
Long? RNAs come in all different lengths, as measured by the number of chemical subunits in the strand. ?Long? versions, sometimes called ?large,? are at least 200 chemical units long, while RNAs of the ?micro? variety typically have around 22 units.
Intergenic? ?Intergenic? refers to RNAs that are copied from portions of the DNA that sit in regions between protein-coding genes. But the designation is becoming less meaningful as scientists discover that these regions yield RNAs with important tasks.
Noncoding? Messenger RNAs are decoded in a cell?s ribosome to make proteins; ?noncoding? refers to RNAs that do not end up as codes for proteins.
RNA? RNA, for ?ribonucleic acid,? is a chemical cousin to DNA, created from the DNA template in a process known as transcription. DNA is made up of the chemical subunits adenine (A), thymine (T), cytosine (C) and guanine (G). RNA substitutes uracil (U) for the T.Found in: Humans
Source: http://www.sciencenews.org/view/feature/id/336570/title/Missing_Lincs
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Labor board moves ahead with union rules (AP)
WASHINGTON ? The National Labor Relations Board on Wednesday moved ahead with plans to speed the pace of union elections, even as Republicans in Congress threatened to derail the process.
The board's Democratic majority voted 2-1 in favor of a revised proposal that could give organized labor a boost in organizing new members at companies that have long opposed unions.
Business groups have strongly opposed the new rules, saying they amount to ambush elections that don't give company managers enough time to talk to employees. Unions claim the rules help them level the playing field with companies that abuse the legal process to stave off union elections.
The vote came after the board's lone Republican member, Brian Hayes, didn't make good on threats to resign, a move that would have rendered the agency powerless to act.
Hayes said he decided not to quit, even though he strongly opposes the rules and believes Democratic members are not giving him enough time to consider them.
Republicans lawmakers in the House also approved a bill Wednesday aimed at short-circuiting the rules, which could make it more difficult for businesses to resist union organizers. But that measure, passed on a 235-188 vote, is unlikely to go anywhere in the Senate.
The labor board action now paves the way for final approval of the rules later this year, before the board loses a three-member quorum when Democratic member Craig Becker's term expires. The board usually has five members, but Republicans have blocked President Barack Obama from filling two vacancies with recess appointments.
The board's plan would simplify procedures and shorten deadlines for holding union elections after employees at a work site gather enough signatures. NLRB Chairman Mark Pearce said the changes are needed because current rules "are laden with unnecessary delays."
Pearce has said he wants to finalize the rules before the end of this year.
Under current rules, union elections typically take place within 45 to 60 days after a union collects signatures and files a petition. Republicans contend the new rules could shorten that time to as little as 10 days.
The House bill would trump the NLRB plan by delaying elections for at least 35 days. It would also overturn a recent board ruling that makes it easier for smaller groups of workers within companies to organize bargaining units.
Republicans and business groups claim the labor board wants to give unions "quickie" elections without giving employers enough time to respond.
"The board's scheme isn't about modernizing the election process," said Minnesota Rep. John Kline, GOP chairman of the House Committee on Education and the Workforce. "This is a draconian effort to stifle employer speech and ambush workers with a union election."
Unions and Democrats say the new rules seek to prevent unnecessary litigation and frivolous appeals that can hold up elections for months.
"What we see is endless delays, endless running up of legal costs of attorneys on both sides, all in the idea of buying time for the employer to intimidate the employees from joining the union," said California Rep. George Miller, top Democrat on the House Education and the Workforce committee.
Hayes claimed he has not been given enough time to review the rules and prepare a dissent. He also argued that the board is disregarding precedent by trying to approve new rules with just two members.
Pearce, the board chairman, disagreed, saying "This has been the most open and participatory proceeding in the 76 years of the board's existence."
___
Follow Sam Hananel on Twitter at http://twitter.com/shananel
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